BioTech Encyclopedia

Materials researched for toxicology

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lab Gadolinium 2014

Gadolinium traces in the brain

Kanda and colleagues found that high signal in the brain's dentate nucleus and globus pallidus on unenhanced T1-weighted MRI correlated with the number of earlier gadolinium-based contrast doses.

As reported in: Kanda, Ishii, Kawaguchi et al. (2014). High Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-weighted MR Images: Relationship with Increasing Cumulative Dose of a Gadolinium-based Contrast Material. Radiology. doi:10.1148/radiol.13131669

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lab Plutonium 2011

How cells take up plutonium

Jensen and colleagues found rat adrenal (PC12) cells can take up plutonium through the iron-transport protein transferrin, but only when plutonium is bound in transferrin's C-lobe and iron in its N-lobe.

As reported in: Jensen, Gorman-Lewis, Aryal et al. (2011). An iron-dependent and transferrin-mediated cellular uptake pathway for plutonium. Nature Chemical Biology. doi:10.1038/nchembio.594

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review Tellurium 2009

Tellurite toxicity and resistance

Chasteen and colleagues reviewed tellurium biology: unlike selenium it has not been found to be an essential trace element, and its soluble oxyanions tellurite and tellurate are toxic to most forms of life even at very low concentrations.

As reported in: Chasteen, Fuentes, Tantaleán et al. (2009). Tellurite: history, oxidative stress, and molecular mechanisms of resistance. FEMS Microbiology Reviews. doi:10.1111/j.1574-6976.2009.00177.x

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review Polonium 2007

Polonium-210 as a poison

After the 2006 death of Alexander Litvinenko, Harrison, Leggett and Lloyd evaluated human and animal data and dose models for ingested polonium-210 and concluded bone marrow failure is likely an important part of fatal damage.

As reported in: Harrison, Leggett, Lloyd et al. (2007). Polonium-210 as a poison. Journal of Radiological Protection. doi:10.1088/0952-4746/27/1/001

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lab Radon 2004

Radon in homes and lung cancer

Pooling 13 European case-control studies with 7,148 lung cancer cases, Darby and colleagues found lung cancer risk rose 16% per 100 Bq/m3 of usual home radon, with no evidence of a threshold.

As reported in: Darby, Hill, Auvinen et al. (2004). Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies. BMJ. doi:10.1136/bmj.38308.477650.63

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lab Beryllium 1989

Beryllium-specific T cells drive lung disease

Saltini and colleagues found that in chronic beryllium disease, beryllium acts as an antigen that makes beryllium-specific CD4+ helper T cells multiply and build up in the lungs, so the disease is a hypersensitivity reaction to beryllium.

As reported in: Saltini, Winestock, Kirby et al. (1989). Maintenance of Alveolitis in Patients with Chronic Beryllium Disease by Beryllium-Specific Helper T Cells. New England Journal of Medicine. doi:10.1056/nejm198904273201702

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lab Lead 1979

Childhood lead and school performance

Needleman and colleagues found children with high lead levels in their teeth (dentine) scored lower on IQ, speech-processing and attention tests than children with low levels, and teacher-rated classroom problems rose with dentine lead.

As reported in: Needleman, Gunnoe, Leviton et al. (1979). Deficits in Psychologic and Classroom Performance of Children with Elevated Dentine Lead Levels. New England Journal of Medicine. doi:10.1056/nejm197903293001301

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