Also: circadian clock, period gene, 2017 Nobel Prize, Hall Rosbash Young, day length
Almost all living things keep a roughly 24-hour internal clock. Work on the fruit fly period gene led to the 2017 Nobel Prize for Jeffrey Hall, Michael Rosbash and Michael Young.
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Konopka and Benzer found three fruit fly mutants with altered daily rhythms (one arrhythmic, one 19-hour and one 28-hour), all in the same gene on the X chromosome, later called period.
As reported in: Konopka, Benzer (1971). Clock Mutants of Drosophila melanogaster. Proceedings of the National Academy of Sciences. doi:10.1073/pnas.68.9.2112
Hardin, Hall and Rosbash reported that the protein made by the Drosophila period gene feeds back on the daily cycling of its own messenger RNA.
As reported in: Hardin, Hall, Rosbash (1990). Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature. doi:10.1038/343536a0
Abstract only