BioTech Encyclopedia

Cell membranes and ion channels: uses in research

Also: potassium channel, KcsA, selectivity filter, Roderick MacKinnon, 2003 Nobel Prize

Ion channels are protein pores in cell membranes that let specific ions through. Roderick MacKinnon's potassium channel structure earned a share of the 2003 Nobel Prize in Chemistry.

Known properties: Cell membranes and ion channels

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  1. 1998 Structure of the potassium channel

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lab biology 1998

Structure of the potassium channel

Doyle, MacKinnon and colleagues solved the structure of a bacterial potassium channel, in which four subunits form a cone around a narrow 12 Å selectivity filter lined with oxygen atoms that fits potassium ions but not smaller sodium ions.

As reported in: Doyle, Cabral, Pfuetzner et al. (1998). The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity. Science. doi:10.1126/science.280.5360.69

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