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Hodgkin and Huxley gave a quantitative description of membrane current and its role in nerve conduction and excitation.
As reported in: Hodgkin, Huxley (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of Physiology. doi:10.1113/jphysiol.1952.sp004764
Kermack and McKendrick developed a mathematical theory of epidemic spread, the origin of SIR models.
As reported in: Kermack, McKendrick (1927). A contribution to the mathematical theory of epidemics. Proceedings of the Royal Society of London. Series A, Containing Papers of a Mathematical and Physical Character. doi:10.1098/rspa.1927.0118