Accidental discovery of platinum effects
Rosenberg and colleagues found that products from platinum electrodes stopped bacteria from dividing.
As reported in: ROSENBERG, VAN CAMP, KRIGAS (1965). Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode. Nature. doi:10.1038/205698a0
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Platinum anticancer compounds
Rosenberg and colleagues reported platinum compounds as potent antitumor agents, leading to cisplatin.
As reported in: ROSENBERG, VANCAMP, TROSKO et al. (1969). Platinum Compounds: a New Class of Potent Antitumour Agents. Nature. doi:10.1038/222385a0
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How cisplatin works
Dasari and Tchounwou reviewed how cisplatin damages cancer cell DNA.
As reported in: Dasari, Bernard Tchounwou (2014). Cisplatin in cancer therapy: Molecular mechanisms of action. European Journal of Pharmacology. doi:10.1016/j.ejphar.2014.07.025
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