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X-rays (crystallography, imaging): uses in research

Also: X-ray diffraction, phase-contrast imaging

X-rays reveal the atomic structure of molecules and the inside of the body.

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Timeline

  1. 1953 Photo 51 era DNA diffraction
  2. 1958 First protein structure
  3. 2006 Phase-contrast X-ray imaging

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lab biology 1953

Photo 51 era DNA diffraction

Franklin and Gosling reported X-ray diffraction of DNA (sodium thymonucleate) fibres.

As reported in: FRANKLIN, GOSLING (1953). Molecular Configuration in Sodium Thymonucleate. Nature. doi:10.1038/171740a0

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lab biology 1958

First protein structure

Kendrew and colleagues obtained a three-dimensional model of myoglobin by X-ray analysis.

As reported in: Kendrew, Bodo, Dintzis et al. (1958). A Three-Dimensional Model of the Myoglobin Molecule Obtained by X-Ray Analysis. Nature. doi:10.1038/181662a0

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biomedical

lab biomedical 2006

Phase-contrast X-ray imaging

Pfeiffer and colleagues achieved differential phase-contrast X-ray imaging with ordinary low-brilliance X-ray tubes.

As reported in: Pfeiffer, Weitkamp, Bunk et al. (2006). Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources. Nature Physics. doi:10.1038/nphys265

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