BioTech Encyclopedia

Naked mole-rat

Experiments: basic research on living systems, not technology.

Also: Heterocephalus glaber

A long-lived rodent that resists cancer, survives without oxygen for minutes and does not seem to age.

Known properties: Naked mole-rat

Only what the cited papers report.

Key measured values

Values as stated in the cited paper's abstract.

PropertyValueSource
Maximum lifespan>30 yearsTian 2013
Hyaluronan size vs human/mouse>5× largerTian 2013
Survival of total anoxia18 minutesPark 2017

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Timeline

  1. 2013 Cancer resistance from giant hyaluronan
  2. 2017 18 minutes without oxygen
  3. 2018 Death risk does not rise with age

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lab biology 2013

Cancer resistance from giant hyaluronan

Tian and colleagues found naked mole-rat cells make hyaluronan over five times larger than mouse or human; removing it made the cells able to form tumours.

As reported in: Tian, Azpurua, Hine et al. (2013). High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature. doi:10.1038/nature12234

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lab biology 2018

Death risk does not rise with age

Ruby, Smith and Buffenstein analysed over 3,000 lifespan records and found mortality risk did not increase with age.

As reported in: Ruby, Smith, Buffenstein (2018). Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age. eLife. doi:10.7554/eLife.31157

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lab biology 2017

18 minutes without oxygen

Park and colleagues found naked mole-rats survive 18 minutes of anoxia by switching to fructose-fuelled metabolism.

As reported in: Park, Reznick, Peterson et al. (2017). Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat. Science. doi:10.1126/science.aab3896

Read free · repository copy

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