Also: Wolbachia pipientis, wMel, World Mosquito Program, cytoplasmic incompatibility, dengue
Wolbachia are bacteria living inside many insects and other invertebrates that manipulate their hosts' reproduction. Mosquitoes carrying one strain are less able to spread dengue.
Values as stated in the cited paper's abstract.
| Property | Value | Source |
|---|---|---|
| Dengue cases, intervention vs control clusters | 2.3% vs 9.4% | Utarini 2021 |
| Protective efficacy against confirmed dengue | 77.1% | Utarini 2021 |
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Werren, Baldo and Clark reviewed the biology of Wolbachia, endosymbiotic bacteria found in arthropods and nematodes.
As reported in: Werren, Baldo, Clark (2008). Wolbachia: master manipulators of invertebrate biology. Nature Reviews Microbiology. doi:10.1038/nrmicro1969
Abstract only
Walker and colleagues introduced the wMel Wolbachia strain into Aedes aegypti mosquitoes; it blocked dengue, caused the reproductive effect cytoplasmic incompatibility with minimal apparent cost, and spread through caged populations.
As reported in: Walker, Johnson, Moreira et al. (2011). The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations. Nature. doi:10.1038/nature10355
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Utarini and colleagues ran a cluster-randomized trial in Yogyakarta, Indonesia; releasing wMel-carrying mosquitoes gave 77.1% protective efficacy against confirmed dengue and 86.2% against dengue hospitalization.
Built / tested: wMel mosquito releases
As reported in: Utarini, Indriani, Ahmad et al. (2021). Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue. New England Journal of Medicine. doi:10.1056/NEJMoa2030243