Proteinaceous infectious particles cause scrapie
Prusiner presented six lines of evidence that the scrapie agent needs a protein to be infectious and resists procedures that modify nucleic acids, and proposed the term prion for this new kind of agent.
As reported in: Prusiner (1982). Novel Proteinaceous Infectious Particles Cause Scrapie. Science. doi:10.1126/science.6801762
Abstract only